李明乐，深圳大学预聘-长聘制副教授，2023年国家海外高层次人才青年项目入选者。2019年博士毕业于大连理工大学，师从我国智能分子材料专家、中国科学院院士彭孝军教授。2019年12月-2023年6月担任韩国高丽大学化学系研究教授（Jong Seung Kim院士团队）、Brain Pool学者。2023年6月回国加入必威。主要研究方向为智能光敏染料、生物光催化、纳米医学、肿瘤光/声动/免疫医学及其相关的临床转化。

近五年，以第一作者或通讯作者发表论文24篇，包括JACS 8篇、Angew 1篇、PNAS 1篇、Chem 2篇、Matter 1篇、Biosens. Bioelectron. 1篇、Chem. Soc. Rev. 1篇、Acc. Chem. Res. 1篇、Coord. Chem. Rev. 4篇。论文累计他人引用2000余次，H因子22，高被引论文6篇；其中，单篇SCI最高引用391次（Web of science）。获得授权国家发明专利4项、日本专利1项、欧洲专利1项、美国专利2项，并有三项研究实现技术转化。主持韩国KRF/BP基金1项（结题）、国家自然科学基金优秀青年基金（海外）项目1项、国家自然科学基金青年基金1项。获2020年度化学化工与材料京博博士论文优秀奖（全国19人），并入选BRIC2022、2023（韩国高影响力学者榜单）、韩国百佳研究团队成员。目前担任Asian J. Pharm. Sci.（JCR1区，IF=10.2）和View（JCR1区，IF=8.6）期刊青年编委。

主要研究方向为:

1. 功能光敏染料（荧光/光声成像、诊疗等方向）

2. 纳米医学（药物递送、RNA等方向）

3. 生物光催化

4. 肿瘤光、热、声动治疗

5. 抗肿瘤免疫

First(Co-first) author：

13.Li, M.; Kim, J.; Rha, H.; Son, S.; Levine, M.; Xu, Y.; Sessler, J.; Kim, J. S. Photon-Controlled Pyroptosis Activation (PhotoPyro): An EmergingTrigger for Antitumor Immune Response.J. Am. Chem. Soc.2023,145,6007-6023.

12.Li, M.; Kim, J.; Xu, Y.; Kim, J. S.An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors.Matter2023,6,15-18.

11.Li, M.; Xu, Y.; Rhee, H-W; Kim, J. S.Deep-red-light photocatalytic protein proximity labelling,Chem2022,8,3171-3174.

10.Li, M.; Gebremedhin, K. H.; Ma, D.; Pu, Z.; Xiong, T.; Xu, Y.; Kim, J. S.; Peng, X. Conditionally Activatable Photoredox Catalysis in Living Systems.J. Am. Chem. Soc.2022,144, 163-173.

9.Li, M.; Xu, Y.; Peng, X.; Kim, J. S. From Low to No O₂-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective.Acc. Chem. Res.2022,55, 3253-3264.

8.Li, M.; Xu, Y.; Pu, Z.; Xiong, T.; Huang, H.; Long, S.; Son, S.; Yu, L.; Singh, N.; Tong, Y.; Sessler, J. L.; Peng, X.; Kim, J. S. Photoredox catalysis may be a general mechanism of photodynamic therapy.Proc. Natl. Acad. Sci. U.S.A.2022,119,e2210504119.

7. Won, M.#;Li, M.#; Kim, H. S.#; Liu, P.#; Koo, S.#; Son, S.; Seo, J. H.; Kim, J. S., Visible to mid IR: A library of multispectral diagnostic imaging.Coordin. Chem. Rev.2021,426, 213608.

6.Li, M.; Shao, Y.; Kim, J. H.; Pu, Z.; Zhao, X.; Huang, H.; Xiong, T.; Kang, Y.; Li, G.; Shao, K., Fan, J., Foley, J. W., Kim, J. S., Peng, X. Unimolecular photodynamic O₂-economizer to overcome hypoxia resistance in phototherapeutics.J. Am. Chem. Soc.2020,142, 5380-5388.

5.Li, M.; Xiong, T.; Du, J.; Tian, R.; Xiao, M.; Guo, L.; Long, S.; Fan, J.; Sun, W.; Shao, K., Song, X., Foley, J. W., Peng, X. Superoxide radical photogenerator with amplification effect: surmounting the Achilles’ heels of photodynamic oncotherapy.J. Am. Chem. Soc.2019,141, 2695-2702.

4.Li, M.; Long, S.; Kang, Y.; Guo, L.; Wang, J.; Fan, J.; Du, J.; Peng, X. De novo design of phototheranostic sensitizers based on structure-inherent targeting for enhanced cancer ablation.J. Am. Chem. Soc.2018,140, 15820-15826.

3.Li, M.; Xia, J.; Tian, R.; Wang, J.; Fan, J.; Du, J.; Long, S.; Song, X.; Foley, J. W.; Peng, X. Near-infrared light-initiated molecular superoxide radical generator: rejuvenating photodynamic therapy against hypoxic tumors.J. Am. Chem. Soc.2018,140, 14851-14859.

2.Li, M.; Tian, R.; Fan, J.; Du, J.; Long, S.; Peng, X. A lysosome-targeted BODIPY as potential NIR photosensitizer for photodynamic therapy.Dyes Pigm.2017,147, 99-105.

1.Li, M.; Peng, X. Research progress on the phthalocyanine based targeting photosensitizers in photodynamic therapy.Acta Chim. Sinica,2016,74, 959-968.

Corresponding author

11. Yu, L.; Lee, K-W.; Zhao, Y-Q.; Xu, Y.; Zhou, Y.*;Li, M.*; Kim, J. S.* Metal Modulation: An Effortless Tactic for Refining Photoredox Catalysis in Living Cells.Inorg. Chem.2023,in press.

10.Singh, N.; Won, M.; Xu, Y.; Yoon, C.; Yoo, J.;Li, M.*; Kang, H.*; Kim, J. S.* Covalent organic framework nanoparticles: Overcoming the challenges of hypoxia in cancer therapy.Coordin. Chem. Rev.2023,499, 215481.

9.Yu, L.; Abedi, A.; Lee, J.; Xu, Y.; Son, S.; Chi, W.;Li, M.*; Liu, X.*; Park, J. H.*; Kim, J. S.* Blending Low-Frequency Vibrations and Push–Pull Effects Affords Superior Photoacoustic Imaging Agents.Angew. Int. Ed. Chem.2023,e202307797.

8.Xu, Y.; Kim, J. S.*;Li, M.*Illuminating anti-ageing.Nat. Chem.2023,15, 451-452.

7. Park, M.; Sunwoo, K.; Kim, Y-J.; Won, M.; Xu, Y.; Kim, J.; Pu, Z.;Li, M.*; Kim, J. Y.*; Seo, J. H.*; Kim, J. S.*Cutting Off H⁺Leaks on Inner Mitochondrial Membrane: A ProtonModulation Approach to Selectively Eradicate Cancer Stem Cells.J. Am. Chem. Soc.2023,145,4647-4658.

6. Zheng, L.*; Zhang, H.; Won, M.; Kim, E.;Li, M.*; Kim, J. S.*Codoping g-C₃N₄with boron and graphene quantum dots: enhancement of charge transfer for ultrasensitive and selective photoelectrochemical detection of dopamine.Biosens. Bioelectron.2023,224, 115050.

5. Xiong, H.; Xu, Y.; Kim, B.; Rha, H.; Zhang, B.;Li, M.*; Yang, G-F.*; Kim, J. S.* Photo-Controllable Biochemistry: Exploiting Photocages in the Phototherapeutic Window.Chem2023,9,29-64.

4. Son, S.; Kim, J.; Kim, J.; Kim, B.; Lee, J.; Kim, Y.;Li, M.*; Kang, H.*; Kim, J. S.* Cancer therapeutics based on diverse energy sources.Chem. Soc. Rev.2022,51, 8201-8215

3. Yu, L.; Xu, Y.; Pu, Z.; Kang, H.;Li, M.*; Sessler, J. L.*; Kim, J. S.* Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells.J. Am. Chem. Soc.2022,144, 11326-11337.

2. Xu, Y.; Xiong, H.; Zhang, B.; Lee, I.; Xie, J.;Li, M.*; Zhang, H.*; Kim, J. S.* Photodynamic Alzheimer’s disease therapy: From molecular catalysis to photo-nanomedicine.Coordin. Chem. Rev.2022,470, 214726.

1. Chu, H.; Yang, L.; Yu, L.; Kim, J.; Zhou, J.*;Li, M.*; Kim, J. S.* Fluorescent probes in public health and public safety.Coordin. Chem. Rev.2021,449, 214208.

2020-2023，韩国KFR/BP基金，已结题，主持；

2024-2026，国家自然科学基金青年科学基金项目，在研，主持；

2024-2026，国家自然科学基金优秀青年科学基金（海外）项目，在研，主持；

2023年，入选国家海外高层次人才青年项目；

2020年，京博科技奖-化学化工与材料京博博士论文优秀奖（全国19人）；